An R package developed to support model-based classification, using genetic data, of the cause of recurrent Plasmodium vivax malaria, i.e. the Pv3Rs:
- Relapse
- Reinfection
- Recrudescence
The R package is currently under development; however, a model around which it is being developed is already published: Taylor & Watson et al. 2019.
Genetic data are modelled using a Bayesian model, whose prior is ideally informative, because the cause of recurrent P. vivax malaria is not always identifiable from genetic data alone (when the data suggest that recurrent parasites are relatively unrelated to those in all preceding infections, both reinfection and relapse are plausible; meanwhile, when the data suggest that recurrent parasites are clones of those in the preceding infection, both recrudescence and relapse are plausible).