diff --git a/Cargo.toml b/Cargo.toml
index b9357bce..581b3f21 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -52,6 +52,8 @@ rustc-dep-of-std = [
   "libc/rustc-dep-of-std",
   "wasi/rustc-dep-of-std",
 ]
+# Enable support for sanitizers; Requires Rust feature `cfg_sanitize`.
+unstable-sanitize = []
 # Unstable/test-only feature to run wasm-bindgen tests in a browser
 test-in-browser = []
 
diff --git a/src/custom.rs b/src/custom.rs
index 79be7fc2..29b62815 100644
--- a/src/custom.rs
+++ b/src/custom.rs
@@ -96,6 +96,9 @@ pub fn getrandom_inner(dest: &mut [MaybeUninit<u8>]) -> Result<(), Error> {
     // compatibility with implementations that rely on that (e.g. Rust
     // implementations that construct a `&mut [u8]` slice from `dest` and
     // `len`).
+    // XXX: Because we do this, memory sanitizer isn't able to detect when
+    // `__getrandom_custom` fails to fill `dest`, but we can't poison `dest`
+    // here either, for the same reason we have to fill it in the first place.
     let dest = uninit_slice_fill_zero(dest);
     let ret = unsafe { __getrandom_custom(dest.as_mut_ptr(), dest.len()) };
     match NonZeroU32::new(ret) {
diff --git a/src/lib.rs b/src/lib.rs
index d1e9ef09..170478ab 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -34,6 +34,19 @@
 //!
 //! Pull Requests that add support for new targets to `getrandom` are always welcome.
 //!
+//! ## Memory Sanitizer (msan) support
+//!
+//! The `unstable-sanitize` feature adds Memory Sanitizer support. You must use
+//! Rust Nightly, e.g.
+//! ```sh
+//! RUSTFLAGS="-Zsanitizer=memory" \
+//!   cargo +nightly test \
+//!   -Zbuild-std --target=x86_64-unknown-linux-gnu --features=unstable-sanitize
+//! ```
+//! It is assumed that libstd/libc have had their APis instrumented to support
+//! sanitizers, so we only provide special support on Linux when using the
+//! `getrandom` syscall.
+//!
 //! ## Unsupported targets
 //!
 //! By default, `getrandom` will not compile on unsupported targets, but certain
@@ -208,6 +221,7 @@
 #![no_std]
 #![warn(rust_2018_idioms, unused_lifetimes, missing_docs)]
 #![cfg_attr(docsrs, feature(doc_auto_cfg))]
+#![cfg_attr(feature = "unstable-sanitize", feature(cfg_sanitize))]
 
 #[macro_use]
 extern crate cfg_if;
diff --git a/src/linux_android.rs b/src/linux_android.rs
index 7c1fede4..156daee0 100644
--- a/src/linux_android.rs
+++ b/src/linux_android.rs
@@ -1,5 +1,5 @@
 //! Implementation for Linux / Android without `/dev/urandom` fallback
-use crate::{util_libc, Error};
+use crate::{util, util_libc, Error};
 use core::mem::MaybeUninit;
 
 pub fn getrandom_inner(dest: &mut [MaybeUninit<u8>]) -> Result<(), Error> {
@@ -8,12 +8,22 @@ pub fn getrandom_inner(dest: &mut [MaybeUninit<u8>]) -> Result<(), Error> {
 
 // Also used by linux_android_with_fallback to check if the syscall is available.
 pub fn getrandom_syscall(buf: &mut [MaybeUninit<u8>]) -> libc::ssize_t {
-    unsafe {
+    let res = unsafe {
         libc::syscall(
             libc::SYS_getrandom,
             buf.as_mut_ptr().cast::<core::ffi::c_void>(),
             buf.len(),
             0,
-        ) as libc::ssize_t
-    }
+        )
+    } as libc::ssize_t;
+    if let Ok(written) = usize::try_from(res) {
+        // XXX: LLVM has support to do this automatically if/when libc is
+        // compiled with it, but glibc that ships in typical Linux distros
+        // doesn't. Assume Android's Bionic is similar. `-Zsanitizer=memory`
+        // is not compatible with `+crt-static` according to rustc.
+        unsafe {
+            unpoison(buf.as_mut_ptr(), written);
+        }
+    };
+    res
 }
diff --git a/src/util.rs b/src/util.rs
index 9eeba9a7..3beeb1d8 100644
--- a/src/util.rs
+++ b/src/util.rs
@@ -46,3 +46,20 @@ fn ptr_from_mut<T: ?Sized>(r: &mut T) -> *mut T {
 fn ptr_from_ref<T: ?Sized>(r: &T) -> *const T {
     r
 }
+
+#[allow(unused_variables)]
+pub unsafe fn unpoison(ptr: *mut MaybeUninit<u8>, len: usize) {
+    #[cfg(feature = "unstable-sanitize")]
+    {
+        // XXX: `#![feature(cfg_sanitize)]` doesn't enable the feature gate correctly.
+        //#[cfg(sanitize = "memory")]
+        {
+            use core::ffi::c_void;
+            extern "C" {
+                // void __msan_unpoison(const volatile void *a, size_t size);
+                fn __msan_unpoison(a: *mut c_void, size: usize);
+            }
+            __msan_unpoison(ptr.cast::<c_void>(), len)
+        }
+    }
+}
diff --git a/tests/common/mod.rs b/tests/common/mod.rs
index 6f283e09..29efcb3a 100644
--- a/tests/common/mod.rs
+++ b/tests/common/mod.rs
@@ -109,6 +109,26 @@ fn test_huge() {
 fn test_huge_uninit() {
     let mut huge = [MaybeUninit::uninit(); 100_000];
     getrandom_uninit_impl(&mut huge).unwrap();
+    check_initialized(&huge);
+}
+
+#[allow(unused_variables)]
+fn check_initialized(buf: &[MaybeUninit<u8>]) {
+    #[cfg(feature = "unstable-sanitize")]
+    {
+        // XXX: `#![feature(cfg_sanitize)]` doesn't enable the feature gate correctly.
+        // #[cfg(sanitize = "memory")]
+        {
+            use core::ffi::c_void;
+            extern "C" {
+                // void __msan_check_mem_is_initialized(const volatile void *x, size_t size);
+                fn __msan_check_mem_is_initialized(x: *const c_void, size: usize);
+            }
+            unsafe {
+                __msan_check_mem_is_initialized(buf.as_ptr().cast::<c_void>(), buf.len());
+            }
+        }
+    }
 }
 
 // On WASM, the thread API always fails/panics