diff --git a/config/http_config.go b/config/http_config.go
index 6c0c033d..6b3609a1 100644
--- a/config/http_config.go
+++ b/config/http_config.go
@@ -380,17 +380,18 @@ func NewRoundTripperFromConfig(cfg HTTPClientConfig, name string, optFuncs ...HT
 			ExpectContinueTimeout: 1 * time.Second,
 			DialContext:           dialContext,
 		}
-		if opts.http2Enabled || os.Getenv("PROMETHEUS_COMMON_ENABLE_HTTP2") != "" {
-			// HTTP/2 support is golang has many problematic cornercases where
+		if opts.http2Enabled && os.Getenv("PROMETHEUS_COMMON_DISABLE_HTTP2") == "" {
+			// HTTP/2 support is golang had many problematic cornercases where
 			// dead connections would be kept and used in connection pools.
 			// https://github.com/golang/go/issues/32388
 			// https://github.com/golang/go/issues/39337
 			// https://github.com/golang/go/issues/39750
 
-			// Enable HTTP2 if the environment variable
-			// PROMETHEUS_COMMON_ENABLE_HTTP2 is set.
-			// This is a temporary workaround so that users can safely test this
-			// and validate that HTTP2 can be enabled Prometheus-Wide again.
+			// Do not enable HTTP2 if the environment variable
+			// PROMETHEUS_COMMON_DISABLE_HTTP2 is set to a non-empty value.
+			// This allows users to easily disable HTTP2 in case they run into
+			// issues again, but will be removed once we are confident that
+			// things work as expected.
 
 			http2t, err := http2.ConfigureTransports(rt.(*http.Transport))
 			if err != nil {