diff --git a/.github/compatibility-test-matrices/main/client-chain-a.json b/.github/compatibility-test-matrices/main/client-chain-a.json
new file mode 100644
index 00000000000..7bec03195cd
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/client-chain-a.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "entrypoint": ["TestClientTestSuite"],
+  "test": [
+    "TestClientUpdateProposal_Succeeds"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/client-chain-b.json b/.github/compatibility-test-matrices/main/client-chain-b.json
new file mode 100644
index 00000000000..ec7a3539054
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/client-chain-b.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestClientTestSuite"],
+  "test": [
+    "TestClientUpdateProposal_Succeeds"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/connection-chain-a.json b/.github/compatibility-test-matrices/main/connection-chain-a.json
new file mode 100644
index 00000000000..b0da913249c
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/connection-chain-a.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "entrypoint": ["TestConnectionTestSuite"],
+  "test": [
+    "TestMaxExpectedTimePerBlockParam"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/connection-chain-b.json b/.github/compatibility-test-matrices/main/connection-chain-b.json
new file mode 100644
index 00000000000..d90e3559677
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/connection-chain-b.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestConnectionTestSuite"],
+  "test": [
+    "TestMaxExpectedTimePerBlockParam"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/ica-chain-a.json b/.github/compatibility-test-matrices/main/ica-chain-a.json
new file mode 100644
index 00000000000..e3d639c1db2
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/ica-chain-a.json
@@ -0,0 +1,12 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestInterchainAccountsTestSuite"],
+  "test": [
+    "TestMsgSendTx_SuccessfulTransfer",
+    "TestMsgSendTx_FailedTransfer_InsufficientFunds",
+    "TestMsgSubmitTx_SuccessfulTransfer_AfterReopeningICA"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/ica-gov-chain-a.json b/.github/compatibility-test-matrices/main/ica-gov-chain-a.json
new file mode 100644
index 00000000000..e2f7c3556dd
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/ica-gov-chain-a.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestInterchainAccountsGovTestSuite"],
+  "test": [
+    "TestInterchainAccountsGovIntegration"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/ica-groups-chain-a.json b/.github/compatibility-test-matrices/main/ica-groups-chain-a.json
new file mode 100644
index 00000000000..10efcc216dc
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/ica-groups-chain-a.json
@@ -0,0 +1,10 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestInterchainAccountsGroupsTestSuite"],
+  "test": [
+    "TestInterchainAccountsGroupsIntegration"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/incentivized-ica-chain-a.json b/.github/compatibility-test-matrices/main/incentivized-ica-chain-a.json
new file mode 100644
index 00000000000..9899cf46895
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/incentivized-ica-chain-a.json
@@ -0,0 +1,11 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestIncentivizedInterchainAccountsTestSuite"],
+  "test": [
+    "TestMsgSendTx_SuccessfulBankSend_Incentivized",
+    "TestMsgSendTx_FailedBankSend_Incentivized"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/incentivized-transfer-chain-a.json b/.github/compatibility-test-matrices/main/incentivized-transfer-chain-a.json
new file mode 100644
index 00000000000..94c28444c6b
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/incentivized-transfer-chain-a.json
@@ -0,0 +1,15 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1"],
+  "entrypoint": ["TestIncentivizedTransferTestSuite"],
+  "test": [
+    "TestMsgPayPacketFee_AsyncSingleSender_Succeeds",
+    "TestMsgPayPacketFee_InvalidReceiverAccount",
+    "TestMultiMsg_MsgPayPacketFeeSingleSender",
+    "TestMsgPayPacketFee_SingleSender_TimesOut",
+    "TestPayPacketFeeAsync_SingleSender_NoCounterPartyAddress",
+    "TestMsgPayPacketFee_AsyncMultipleSenders_Succeeds"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/incentivized-transfer-chain-b.json b/.github/compatibility-test-matrices/main/incentivized-transfer-chain-b.json
new file mode 100644
index 00000000000..6553269b9a2
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/incentivized-transfer-chain-b.json
@@ -0,0 +1,15 @@
+{
+  "chain-a": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestIncentivizedTransferTestSuite"],
+  "test": [
+    "TestMsgPayPacketFee_AsyncSingleSender_Succeeds",
+    "TestMsgPayPacketFee_InvalidReceiverAccount",
+    "TestMultiMsg_MsgPayPacketFeeSingleSender",
+    "TestMsgPayPacketFee_SingleSender_TimesOut",
+    "TestPayPacketFeeAsync_SingleSender_NoCounterPartyAddress",
+    "TestMsgPayPacketFee_AsyncMultipleSenders_Succeeds"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/transfer-chain-a.json b/.github/compatibility-test-matrices/main/transfer-chain-a.json
new file mode 100644
index 00000000000..99b607e12da
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/transfer-chain-a.json
@@ -0,0 +1,15 @@
+{
+  "chain-a": ["main"],
+  "chain-b": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "entrypoint": ["TestTransferTestSuite"],
+  "test": [
+    "TestMsgTransfer_Succeeds_Nonincentivized",
+    "TestMsgTransfer_Fails_InvalidAddress",
+    "TestMsgTransfer_Timeout_Nonincentivized",
+    "TestMsgTransfer_WithMemo",
+    "TestSendEnabledParam",
+    "TestReceiveEnabledParam"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/compatibility-test-matrices/main/transfer-chain-b.json b/.github/compatibility-test-matrices/main/transfer-chain-b.json
new file mode 100644
index 00000000000..d64f0be8ffe
--- /dev/null
+++ b/.github/compatibility-test-matrices/main/transfer-chain-b.json
@@ -0,0 +1,15 @@
+{
+  "chain-a": ["main", "v5.1.0", "v5.0.1", "v4.2.0", "v4.1.1", "v3.4.0", "v3.3.1", "v2.5.0", "v2.4.2"],
+  "chain-b": ["main"],
+  "entrypoint": ["TestTransferTestSuite"],
+  "test": [
+    "TestMsgTransfer_Succeeds_Nonincentivized",
+    "TestMsgTransfer_Fails_InvalidAddress",
+    "TestMsgTransfer_Timeout_Nonincentivized",
+    "TestMsgTransfer_WithMemo",
+    "TestSendEnabledParam",
+    "TestReceiveEnabledParam"
+  ],
+  "chain-binary": ["simd"],
+  "chain-image": ["ghcr.io/cosmos/ibc-go-simd"]
+}
diff --git a/.github/workflows/e2e-compatibility.yaml b/.github/workflows/e2e-compatibility.yaml
index c85c0179440..53158a0bd1b 100644
--- a/.github/workflows/e2e-compatibility.yaml
+++ b/.github/workflows/e2e-compatibility.yaml
@@ -13,6 +13,7 @@ on:
           - release/v5.0.x
           - release/v5.1.x
           - release/v6.0.x
+          - main
 
 env:
   REGISTRY: ghcr.io
@@ -45,6 +46,7 @@ jobs:
           - release/v5.0.x
           - release/v5.1.x
           - release/v6.0.x
+          - main
     steps:
       - uses: actions/checkout@v3
         if: env.RELEASE_BRANCH == matrix.release-branch
@@ -179,4 +181,4 @@ jobs:
     uses: ./.github/workflows/e2e-compatibility-workflow-call.yaml
     with:
       test-file-directory: "${{ needs.determine-test-directory.outputs.test-directory }}"
-      test-suite: "ica-gov-chain-a"
\ No newline at end of file
+      test-suite: "ica-gov-chain-a"