diff --git a/.test-infra/tools/README.md b/.test-infra/tools/README.md
index 1c7addfd3941..df6ab9525e9a 100644
--- a/.test-infra/tools/README.md
+++ b/.test-infra/tools/README.md
@@ -47,11 +47,11 @@ Example:
 - Original
 
 ```bash
-python_versions_arr=("3.6.13" "3.7.10" "3.8.9" "3.9.4")
+python_versions_arr=("3.8.16" "3.7.16" "3.9.16" "3.10.10")
 ```
 
 - Change
 
 ```bash
-python_versions_arr=("3.6.13" "3.7.10" "3.9.0" "3.10.2")
+python_versions_arr=("3.8.10" "3.9.0" "3.10.2")
 ```
diff --git a/.test-infra/tools/python_installer.sh b/.test-infra/tools/python_installer.sh
index 0fe73e7fabdd..0b40eb12b993 100644
--- a/.test-infra/tools/python_installer.sh
+++ b/.test-infra/tools/python_installer.sh
@@ -20,7 +20,7 @@
 set -euo pipefail
 
 # Variable containing the python versions to install
-python_versions_arr=("3.8.9" "3.6.13" "3.7.10" "3.9.4" "3.10.1")
+python_versions_arr=("3.8.16" "3.7.16" "3.9.16" "3.10.10")
 
 # Install pyenv dependencies.
 pyenv_dep(){
diff --git a/sdks/python/apache_beam/runners/dataflow/internal/apiclient.py b/sdks/python/apache_beam/runners/dataflow/internal/apiclient.py
index 9ac2ceb98ba9..bed2cdc677a5 100644
--- a/sdks/python/apache_beam/runners/dataflow/internal/apiclient.py
+++ b/sdks/python/apache_beam/runners/dataflow/internal/apiclient.py
@@ -81,7 +81,7 @@
 
 _LOGGER = logging.getLogger(__name__)
 
-_PYTHON_VERSIONS_SUPPORTED_BY_DATAFLOW = ['3.6', '3.7', '3.8', '3.9', '3.10']
+_PYTHON_VERSIONS_SUPPORTED_BY_DATAFLOW = ['3.7', '3.8', '3.9', '3.10']
 
 
 class Step(object):
diff --git a/website/www/site/content/en/get-started/quickstart-py.md b/website/www/site/content/en/get-started/quickstart-py.md
index d09548df2801..aa905998d571 100644
--- a/website/www/site/content/en/get-started/quickstart-py.md
+++ b/website/www/site/content/en/get-started/quickstart-py.md
@@ -23,7 +23,7 @@ If you're interested in contributing to the Apache Beam Python codebase, see the
 
 {{< toc >}}
 
-The Python SDK supports Python 3.6, 3.7, and 3.8. Beam 2.24.0 was the last release with support for Python 2.7 and 3.5.
+The Python SDK supports Python 3.7, 3.8, 3.9 and 3.10. Beam 2.38.0 was the last release with support for Python 3.6.
 
 ## Set up your environment